Clinical Usefulness of 18F-FDG PET/CT in the Detection of Early Recurrence in Treated Cervical Cancer Patients with Unexplained Elevation of Serum Tumor Markers
Chonnam Medical Journal 2013³â 49±Ç 1È£ p.20 ~ p.26
Á¤¾Æ¸®(Chong A-Ri) - Chosun University Hospital Department of Nuclear Medicine
ÇÏÁ¤¹Î(Ha Jung-Min) - Chosun University Hospital Department of Nuclear Medicine
Á¤½Å¿µ(Jeong Shin-Young) - Kyungpook National University Hospital Department of Nuclear Medicine
¼Ûȣõ(Song Ho-Chun) - Chonnam National University Hospital Department of Nuclear Medicine
¹ÎÁ¤ÁØ(Min Jung-Joon) - Chonnam National University Hospital Department of Nuclear Medicine
¹üÈñ½Â(Bom Hee-Seung) - Chonnam National University Hospital Department of Nuclear Medicine
ÃÖÈ£¼±(Choi Ho-Sun) - Chonnam National University Hospital Department of Obstetrics and Gynecology
Abstract
We investigated the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for restaging of treated uterine cervix squamous cell cancer with tumor maker elevation that was not explained by other conventional evaluation. We enrolled 32 cases who underwent PET/CT for the restaging of treated cervical cancer with tumor marker elevation that was not explained by recent conventional evaluation. All enrolled cases had squamous cell carcinoma. Increased tumor markers included squamous cell carcinoma antigen (SCC Ag) and carcinoembryonic antigen (CEA). PET/CT findings were determined by pathologic confirmation or clinical follow-up. We compared PET/CT accuracy and clinical parameters including normalization of tumor markers in both the SCC Ag elevation group and the CEA elevation group. The sensitivity, specificity, positive predictive value, and negative predictive value of PET/CT in detecting recurrence were 100%, 83.3%, 82.4%, and 100%, respectively. Accuracy was significantly different between the SCC Ag elevation group and the CEA elevation group (p=0.0169). PET/CT with SCC Ag elevation was more accurate (100%) than PET/CT with CEA elevation (66.7%). Normalization of tumor markers was observed more often in the SCC Ag elevation group than in the CEA elevation group (p=0.0429). PET/CT showed high negative predictive value and sensitivity in the restaging of cervical cancer with unexplained tumor marker elevation. PET/CT was more accurate in patients with SCC Ag elevation than in those with CEA elevation.
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Fluorodeoxyglucose F18, Positron-emission tomography and computed tomography, Recurrence
KMID :
0880520130490010020
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18F-FDG PET/CT showed high negative predictive value and sensitivity in restaging of cervical cancer with unexplained tumor marker elevation; Accuracy was significantly different between the SCC Ag elevation group and the CEA elevation group (p=0.0169). PET/CT with SCC Ag elevation was more accurate (100%) than PET/CT with CEA elevation (66.7%).